Striving for perfection is ultimately the only justification for the academic enterprise; if you don’t feel comfortable with this goal—e.g. because you think it too presumptuous—, stay out!
Dijkstra presents the pursuit of the highest possible standards as central to academic life. His use of “perfection” is best understood as an ideal to strive towards rather than a claim that flawless work is routinely attainable. The emphasis is on continual refinement, rigour and dissatisfaction with work that could be made substantially better.
The quotation also sets a demanding view of scholarship. Dijkstra suggests that academic work requires more than competence or career advancement; it requires a willingness to submit one’s ideas to exacting standards and to keep improving them. His closing instruction deliberately sharpens that point by treating this commitment as a condition of belonging in academia.
The statement can therefore be read as a defence of intellectual seriousness. It argues that the academic enterprise is justified by the effort to improve knowledge as far as possible, even when that standard is difficult to satisfy.